Clinically Meaningful Improvements in Early Morning and Late Afternoon/Evening Functional Impairment in Children with ADHD Treated with Delayed-Release and Extended-Release Methylphenidate
| Autor: | Norberto J. DeSousa, Cassandra L. Uchida, Floyd R. Sallee, Paul Hammerness, Jeffrey H. Newcorn, Bev Incledon, Timothy E. Wilens, Stephen V. Faraone, Steven R. Pliszka |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Evening Functional impairment methylphenidate Audiology Parent ratings 03 medical and health sciences 0302 clinical medicine Double-Blind Method BSFQ PREMB-R mental disorders Developmental and Educational Psychology medicine ADHD Humans 0501 psychology and cognitive sciences Child Morning Methylphenidate 05 social sciences Articles Delayed release (linguistics) Clinical Psychology functional impairment Treatment Outcome Attention Deficit Disorder with Hyperactivity Delayed-Action Preparations Central Nervous System Stimulants Late afternoon Extended release Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology medicine.drug |
| Zdroj: | Journal of Attention Disorders |
| ISSN: | 1557-1246 1087-0547 |
| DOI: | 10.1177/10870547211020073 |
| Popis: | Objective: The Before School Functioning Questionnaire and Parent Rating of Evening and Morning Behavior–Revised assess early morning (BSFQ, PREMB-R AM subscale) and late afternoon/evening (PREMB-R PM subscale) functional impairment in children with ADHD. Clinically meaningful improvements were identified and applied to a trial of delayed-release and extended-release methylphenidate (DR/ER-MPH) in children with ADHD (NCT02520388) to determine if the statistically-determined improvements in functional impairment were also clinically meaningful. Method: Clinically meaningful improvements in BSFQ/PREMB-R were established post hoc by receiver operating characteristics curves, using anchors of Clinical Global Impression–Improvement (CGI-I) = 1 and CGI-I ≤ 2. Percentages of participants achieving these thresholds were calculated. Results: Thresholds for CGI-I = 1/CGI-I ≤ 2, respectively, were 27/20 (BSFQ), 5/3 (PREMB-R AM), and 9/5 (PREMB-R PM)-point decreases. More children achieved clinically meaningful improvements with DR/ER-MPH versus placebo (all p Conclusion: DR/ER-MPH increased proportions of children achieving clinically meaningful improvements in BSFQ and PREMB-R. |
| Databáze: | OpenAIRE |
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