Infected cat-bite wound treated successfully with moxifloxacin after failure of parenteral cefuroxime and ciprofloxacin
| Autor: | A. Roggenkamp, R. Draenert, M. Kunzelmann, J. R. Bogner, J. Hellers |
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| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.drug_class Antibiotics Moxifloxacin Pasteurella Infections Skin infection Ciprofloxacin Internal medicine Streptococcal Infections Medicine Animals Humans Bites and Stings Treatment Failure Antibacterial agent Aza Compounds Cefuroxime business.industry General Medicine Middle Aged bacterial infections and mycoses Antimicrobial medicine.disease Surgery Anti-Bacterial Agents Infectious Diseases Cellulitis Cats Quinolines Wound Infection Female business medicine.drug Fluoroquinolones |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 24(4) |
| ISSN: | 0934-9723 |
| Popis: | The existing medical literature contains, to the best of our knowledge, no published reports on the efficacy of moxifloxacin in treating infected cat-bite wounds. Nevertheless, in vitro data regarding the sensitivity of typical bite-wound bacteria to moxifloxacin encourage the use of this antibiotic [1, 2]. The high bactericidal activity of moxifloxacin against gram-positive, gram-negative and several anaerobic organisms in conjunction with data on tissue availability of the compound led Bayer Pharmaceuticals to perform two large-scale multicenter trials with moxifloxacin in severe skin and soft tissue infections between 2001 and 2004 (personal communication); however, the results are not yet available. In a study of noncomplicated skin and soft tissue infections, moxifloxacin was found to be equivalent to cephalexin in the treatment of cellulitis and skin infections [3]. In the case presented here, an infected cat-bite wound was successfully treated with intravenous followed by oral moxifloxacin after treatment with parenteral cefuroxime and ciprofloxacin failed. Possible explanations for the success of this therapy are the high tissue levels, broad antimicrobial spectrum, and additional intracellular action of moxifloxacin. A 46-year-old female psychologist experienced two deep cat bites on the right hand and middle finger. Within 7 h |
| Databáze: | OpenAIRE |
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