Oral dydrogesterone in frozen-thawed embryo transfer cycles
| Autor: | Luma Caroline Gomes Mattos de Macedo, Mario Cavagna Neto, Artur Dzik, Andressa do Rosário Rocha, Sônia Maria Rolim Rosa Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Revista da Associação Médica Brasileira n.ahead 2021 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Volume: 68, Issue: 1, Pages: 100-105, Published: 13 DEC 2021 Revista da Associação Médica Brasileira (2021) Revista da Associação Médica Brasileira v.68 n.1 2022 Revista da Associação Médica Brasileira, Issue: ahead, Published: 13 DEC 2021 |
| Popis: | SUMMARY OBJECTIVE: The aim of this study was to compare the use of micronized vaginal progesterone and oral dydrogesterone in the endometrial preparation for frozen-thawed embryo transfer. METHODS: This was a randomized, controlled, open, two-armed clinical trial, with women undergoing frozen-thawed embryo transfer along with hormone replacement therapy for endometrial preparation, between September 2019 and February 2021. A total of 73 patients were randomly selected and orally administered 40 mg/day dydrogesterone (dydrogesterone group, n=36) or 800 mg/day micronized vaginal progesterone (micronized vaginal progesterone group, n=37), after endometrial preparation with transdermal estradiol. The main outcome was a viable ongoing pregnancy with 12 weeks of gestation as evaluated by ultrasound. RESULTS: The reproductive outcomes in frozen-thawed embryo transfer cycles were similar, with pregnancy rates in the dydrogesterone and micronized vaginal progesterone treatment groups being, respectively, 33.3 and 32.4% at 12 weeks pregnancy (confidence interval= -22.4-20.6, p=0.196). CONCLUSIONS: The use of oral dydrogesterone may be a more patient-friendly approach to endometrial preparation in frozen-thawed embryo transfer cycles, avoiding undesirable side effects and discomfort resulting from vaginal administration, while also providing similar reproductive results. |
| Databáze: | OpenAIRE |
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