Optimisation methodology in the chiral and achiral separation in electrokinetic chromatography in the case of a multicomponent sample of dansyl amino acids
| Autor: | Vincenzo Cucinotta, Alessandro Giuffrida, Annalinda Contino, Marianna Messina |
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| Rok vydání: | 2013 |
| Předmět: |
Analyte
Electrokinetic chromatography Clinical Biochemistry Analytical chemistry Pharmaceutical Science Analytical Chemistry Electrokinetic phenomena Drug Discovery Amino Acids Spectroscopy Chromatography Micellar Electrokinetic Capillary Dansyl Compounds chemistry.chemical_classification Chromatography Chemistry Stereoisomerism Hydrogen-Ion Concentration Cyclodextrin Derivatives Sample (graphics) Amino acid Electropherogram Kinetics Cyclodextrin derivatives Chiral separations Amino acids Enantiomer |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 85:55-60 |
| ISSN: | 0731-7085 |
| Popis: | Two different chiral selectors synthesised in our laboratory were used to test the possibility of separation for a sample consisting of ten different enantiomeric pairs of dansyl-derivatives of α-amino acids in electrokinetic chromatography. It was possible to observe all the peaks, though only partly resolved, due to the twenty analytes through an accurate strategy of choice of the experimental conditions. As a part of this strategy, a procedure of identification of the single peaks in the electropherograms called LACI (lastly added component identification) has been developed. |
| Databáze: | OpenAIRE |
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