Photobactericidal Porphyrin-Cellulose Nanocrystals: Synthesis, Characterization, and Antimicrobial Properties
| Autor: | Elke Feese, Hanna S. Gracz, Dimitris S. Argyropoulos, Reza A. Ghiladi, Hasan Sadeghifar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Azides
Staphylococcus aureus Thermogravimetric analysis Magnetic Resonance Spectroscopy Porphyrins Light Polymers and Plastics Mycobacterium smegmatis Bioengineering Microbial Sensitivity Tests 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Gel permeation chromatography chemistry.chemical_compound Species Specificity Polymer chemistry Escherichia coli Materials Chemistry Humans Nanotechnology Cellulose Microbial Viability Photosensitizing Agents Molecular Structure Chemistry Cationic polymerization 021001 nanoscience & nanotechnology Antimicrobial Porphyrin Anti-Bacterial Agents 0104 chemical sciences Thermogravimetry Nanoparticles Click Chemistry Azide 0210 nano-technology Disinfectants |
| Zdroj: | Biomacromolecules. 12:3528-3539 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/bm200718s |
| Popis: | Adherence and survival of pathogenic bacteria on surfaces leading to concomitant transmission to new hosts significantly contributes to the proliferation of pathogens, which in turn considerably increases the threat to human health, particularly by antibiotic-resistant bacteria. Consequently, more research into effective surface disinfection and alternative materials (fabrics, plastics, or coatings) with antimicrobial and other bioactive characteristics is desirable. This report describes the synthesis and characterization of cellulose nanocrystals that were surface-modified with a cationic porphyrin. The porphyrin was appended onto the cellulose surface via the Cu(I)-catalyzed Huisgen-Meldal-Sharpless 1,3-dipolar cycloaddition having occurred between azide groups on the cellulosic surface and porphyrinic alkynes. The resulting, generally insoluble, crystalline material, CNC-Por (5), was characterized by infrared and diffusion (1)H NMR spectroscopies, gel permeation chromatography, and thermogravimetric analysis. Although only suspended, and not dissolved, in an aqueous system, CNC-Por (5) showed excellent efficacy toward the photodynamic inactivation of Mycobacterium smegmatis and Staphylococcus aureus , albeit only slight activity against Escherichia coli . The synthesis, properties, and activity of CNC-Por (5) described herein serve as a benchmark toward our overall objectives of developing novel, potent, bioactive, photobactericidal materials that are effective against a range of bacteria, with potential utilization in the health care and food preparation industries. |
| Databáze: | OpenAIRE |
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