Association of Erythropoietin Resistance with Fatigue in Hemodialysis Patients: A Cross-Sectional Study
| Autor: | Akiyo Yamasaki, Koichiro Yoda, Shigeki Okada, Yoshihiro Tsujimoto, Masaaki Inaba, Hidenori Koyama, Senji Okuno, Shinsuke Yamada |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Anemia medicine.medical_treatment 030232 urology & nephrology 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine medicine Humans In patient 030212 general & internal medicine Erythropoietin Fatigue Aged business.industry fungi food and beverages Middle Aged medicine.disease Cross-Sectional Studies Multivariate Analysis Physical therapy Female Hemodialysis business medicine.drug |
| Zdroj: | Nephron. 134(2) |
| ISSN: | 2235-3186 |
| Popis: | Background/Aims: Fatigue is a common symptom in patients receiving hemodialysis (HD) and is generally associated with anemia. However, it can be difficult to resolve, even when anemia has been treated using erythropoiesis-stimulating agents and iron replacement therapy. In the present study, we examined the associations of anemia, the erythropoietin resistance index (ERI) and iron deficiency with fatigue during HD. Methods: In this cross-sectional study, fatigue score was calculated on the basis of questionnaire responses in HD patients. Participants were divided into 3 groups according to their hemoglobin (Hb) levels (low, normal and high). Iron deficiency was assessed as a transferrin saturation (TSAT) of Results: We included 571 HD patients (men/women 368/203; mean age 62.2 ± 10.8 years). Among the 3 groups, fatigue scores increased significantly with decreasing Hb levels. HD patients with low Hb levels (Conclusion: Iron deficiency and a high ERI despite iron sufficiency may cause fatigue in HD patients. |
| Databáze: | OpenAIRE |
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