Effects of Saline Loading on Distal Renal Tubular Sodium and Water Reabsorption
| Autor: | Marvin F. Levitt, D. Danny Bercovitch |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty Sodium Clearance Sodium Natriuresis Diuresis Renal function chemistry.chemical_element Sodium Chloride General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Dogs Internal medicine medicine Animals Creatinine Reabsorption Creatine Kidney Tubules Endocrinology chemistry Female Saline loading Glomerular Filtration Rate |
| Zdroj: | Experimental Biology and Medicine. 125:552-556 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-125-32143 |
| Popis: | SummaryThe stop flow method was used to determine the effects of saline loading on distal renal tubular function in hydropenic dogs. Stop flow experiments were performed in 6 dogs early and late in the course of an increasing diuresis induced by saline loading. Distal tubular stop flow patterns were compared with regard to the sodium clearance ratio (U/P Na/U/P creatinine) and U/P creatinine values. Stop flow patterns obtained late in the diuresis consistently showed elevations of all distal sodium clearance ratios, including the minimum, and decreases in all U/P creatinine values. These data suggest that an inhibition of sodium and water reabsorption develops in the distal tubule during saline loading. This could be characterized only as a fractional rather than an absolute decrease in distal reabsorption. It appeared that the inhibition was not a flow rate dependent phenomenon. Reabsorption at other tubular sites was not evaluated because of limitations inherent in stop flow methodology. |
| Databáze: | OpenAIRE |
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