Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
| Autor: | Willem J. M. Mulder, Zahi A. Fayad, Stephen D. Dickson, David P. Cormode, Peter A. Jarzyna, Anita Gianella, Daniel D. Samber, Torjus Skajaa, Wei Chen, Arjan W. Griffioen |
|---|---|
| Přispěvatelé: | Medical oncology laboratory, CCA - Innovative therapy, Medical Biochemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Materials science Fluorophore Biophysics Iron oxide Nanoparticle Contrast Media Mice Nude Bioengineering Nanotechnology Biocompatible Materials Ferric Compounds Article Biomaterials chemistry.chemical_compound Mice Drug Delivery Systems In vivo Cell Line Tumor Neoplasms Materials Testing medicine Animals Humans Particle Size Nanocomposite medicine.diagnostic_test Water Magnetic resonance imaging Magnetic Resonance Imaging chemistry Mechanics of Materials Ceramics and Composites Nanoparticles Emulsions Oils Ex vivo Neoplasm Transplantation Biomedical engineering |
| Zdroj: | Biomaterials, 30(36), 6947-6954. Elsevier BV Jarzyna, P A, Skajaa, T, Gianella, A, Cormode, D P, Samber, D D, Dickson, S D, Chen, W, Griffioen, A W, Fayad, Z A & Mulder, W J M 2009, ' Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging ', Biomaterials, vol. 30, no. 36, pp. 6947-6954 . https://doi.org/10.1016/j.biomaterials.2009.09.004 Jarzyna, P A, Skajaa, T, Gianella, A, Cormode, D P, Samber, D D, Dickson, S D, Chen, W, Griffioen, A W, Fayad, Z A & Mulder, W J M 2009, ' Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging ' Biomaterials, vol. 30, no. 36, pp. 6947-54 . https://doi.org/10.1016/j.biomaterials.2009.09.004 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2009.09.004 |
| Popis: | Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl’s staining of histological tumor sections ex vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect