| Autor: |
Masaya Watanabe, Takayoshi Kiguchi, Akihiro C. Yamashita |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 25(4) |
| ISSN: |
1619-0904 |
| Popis: |
An infusion of dialysate into the blood compartment across the membrane using back filtration in dialysis therapy provides a stabilizing blood pressure and a membrane flushing during treatment. We devised a method to flush the membrane effectively and tried to find the optimum infusion patterns for intermittent infusion hemodiafiltration (I-HDF) from the aspect of solute removal by computing the pressure distribution in a diafilter. Bovine blood experiments were performed under following three modes: control HD in which no intentional filtration was involved, and two I-HDF in which back filtration was made either under counter current or under parallel flow. The inner surface of the hollow fiber before and after the experiment was observed using FE-SEM. According to the computation of the pressure distribution, a large amount of normal filtration occurs near the blood inlet in control HD. In addition, when the back filtration is performed under parallel flow, the amount of backfiltration near the blood inlet is 3.43 times higher than that in the case of counter current. Clearance (C |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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