Prognostic Role of Nodal Skip Metastasis in Thoracic Esophageal Squamous Cell Carcinoma: A Large-Scale Multicenter Study
| Autor: | Xiao-Dong Yao, Zhi-Yong Wu, Li-Yan Xu, Yu-Shang Yang, Zhi-Wei Fan, Yong Yuan, Yin Li, Long-Qi Chen, Hong Yang, Yi Li, Qi-Xin Shang, Xiu-E Xu, Jianhua Fu, Jian-Yi Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment 030230 surgery Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma medicine Humans Esophagus Survival rate Neoplasm Staging Retrospective Studies business.industry Hazard ratio Cancer Esophageal cancer Prognosis medicine.disease Esophagectomy Survival Rate medicine.anatomical_structure Head and Neck Neoplasms Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Surgery Esophageal Squamous Cell Carcinoma Lymph Nodes business |
| Zdroj: | Annals of Surgical Oncology. 28:6341-6352 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-020-09509-z |
| Popis: | Nodal-skip metastasis (NSM) is found in esophageal squamous cell carcinoma (ESCC), but its prognostic role is controversial. This study aimed to investigate the prognostic value of NSM for thoracic ESCC patients. Categorization of NSM was according to the N groupings of Japan Esophagus Society (JES) staging system, which is dependent on tumor location. Using the Kaplan–Meier method and Cox-regression analysis, this study retrospectively analyzed the overall survival (OS) for 2325 ESCC patients after radical esophagectomy at three high-volume esophageal cancer centers. Predictive models also were constructed. The overall NSM rate was 20% (229/1141): 37.4% in the in upper, 12.9% in the middle, and 22.2% in the lower thoracic ESCC. The patients with NSM always had a better prognosis than those without NSM. Furthermore, NSM was an independent prognostic factor for thoracic ESCC patients (hazard ratio [HR], 0.633; 95% confidence interval [CI], 0.499–0.803; P |
| Databáze: | OpenAIRE |
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