Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling
| Autor: | Jie Zhao, Hongxing Li, Gui-Mei Zhang, Zuo-Hua Feng, Bo Huang, Jay C. Unkeless, Shiqian Shen, Huabao Xiong, Lloyd Mayer, Dong Li, Kai-Li He, Ye Yuan, Guanxin Shen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Carcinoma Hepatocellular CD30 Cell Growth Processes Biology medicine.disease_cause Mice Stomach Neoplasms Cell Line Tumor medicine Animals Humans Mice Inbred BALB C Toll-like receptor Helicobacter pylori Cell growth Liver Neoplasms NF-kappa B Listeria monocytogenes Toll-Like Receptor 2 Enzyme Activation Killer Cells Natural TLR2 Oncology Cell culture Tumor progression Immunology Cancer research Mitogen-Activated Protein Kinases Signal transduction Carcinogenesis Signal Transduction |
| Zdroj: | Cancer Research. 67:4346-4352 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-06-4067 |
| Popis: | The contribution of bacterial infection to tumorigenesis is usually ascribed to infection-associated inflammation. An alternate view is that direct interaction of bacteria with tumor cells promotes tumor progression. Here, we show that the microenvironment of large tumors favors bacterial survival, which in turn directly accelerates tumor growth by activating tumor cell Toll-like receptors (TLR). Listeria monocytogenes (Lm) survives in the microenvironment of large but not small tumors, resulting in the promotion of tumor growth. Lm did not affect the percentage of regulatory T cells or myeloid suppressor cells in the tumor. Through TLR2 signaling, Lm activated mitogen-activated protein kinases and nuclear factor-κB in tumor cells, resulting in the increased production of nitric oxide and interleukin-6 and increased proliferation of tumor cells. All of these effects were abrogated by silencing expression of TLR2, but not TLR4. The interaction of Helicobacter pylori with tumor cells from gastric carcinoma patients resulted in similar effects. These findings provide a new insight into infection-associated tumorigenesis and illustrate the importance of antibiotic therapy to treat tumors with bacterial infiltration. [Cancer Res 2007;67(9):4346–52] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|