Lung Infection Caused by Mycobacterium riyadhense Confused with Mycobacterium tuberculosis: The First Case in Korea
| Autor: | Jae Bum Jeon, Joseph Jeong, Jae-Sun Park, Seon Ho Lee, Sung-Ryul Kim, Ji-Hun Lim, Kwang Won Seo, Jung-In Choi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Lung Diseases Bacilli Clinical Biochemistry Antitubercular Agents Case Report Microbial Sensitivity Tests Mycobacterium Microbiology Mycolic acid Mycobacterium tuberculosis RNA Ribosomal 16S Republic of Korea medicine Humans Internal transcribed spacer Nontuberculous mycobacteria Chromatography High Pressure Liquid Phylogeny Oligonucleotide Array Sequence Analysis chemistry.chemical_classification Mycobacterium Infections biology Biochemistry (medical) Sequence Analysis DNA General Medicine Mycobacterium riyadhense biology.organism_classification Virology Clinical Microbiology RNA Ribosomal 23S Mycolic Acids Mycobacterium tuberculosis complex chemistry Mycobacterium simulans Sputum Female medicine.symptom |
| Zdroj: | Annals of Laboratory Medicine |
| ISSN: | 2234-3814 2234-3806 |
| Popis: | A slowly growing, non-chromogenic mycobacterial strain was isolated from sputum and bronchial lavage fluid samples of a patient presenting with productive cough, blood-tinged sputum, low-grade fever, and weakness. A positive acid-fast bacilli sputum smear result prompted the initiation of an anti-tuberculosis regimen. Multiplex real-time PCR showed a negative result for Mycobacterium tuberculosis complex and a positive result for nontuberculous mycobacteria. The DNA chip test confirmed this organism as a member of the genus Mycobacterium, but could not specify the species. Interestingly, the mycolic acid patterns obtained by HPLC nearly overlapped with those of M. simulans. The sequences of the Mycobacterium 16S rRNA gene and 16S-23S internal transcribed spacer region were unique and were found to have 100% similarity with those of M. riyadhense. After a review of the literature, we report this case as the first Korean case of M. riyadhense lung infection. |
| Databáze: | OpenAIRE |
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