The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta‐analysis
| Autor: | Billy Lane O’Neill, Marc C Grant-Freemantle, Anthony James P Clover |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis medicine.medical_treatment Lower risk 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine 030223 otorhinolaryngology Head and neck Melanoma Retrospective Studies business.industry Mucosal melanoma Distant metastasis Prognosis medicine.disease Radiation therapy Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Meta-analysis Relative risk Radiotherapy Adjuvant Neoplasm Recurrence Local business |
| Zdroj: | Head & Neck. 43:323-333 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.26470 |
| Popis: | Introduction Mucosal melanoma (MM) is a rare condition with a poor prognosis. Surgery is the corner stone of treatment, however, radiotherapy has been commonly employed as a treatment strategy and recent studies suggesting that survival outcomes may be improving are emerging. Methods A systematic review and meta-analysis comparing risk ratios of radiotherapy and surgery and radiotherapy (SRT) with surgery for 5-year overall survival, local recurrence and distant metastasis in head and neck mucosal melanoma (HNMM). Results SRT has a lower risk of death compared to surgery [RR 0.93 [95% CI = 0.87, 0.98] (P = .01)] and a reduced risk of local recurrence [RR 0.63 [95% CI = 0.48, 0.82] (P = .005)]. SRT has no effect on distant metastasis. Radiotherapy has worse survival when compared to surgery [RR 1.2 [95% CI = 1.03, 1.33] (P = .0006)]. Conclusions SRT confers a moderate survival advantage in HNMM compared to surgery. This is most likely secondary to reduced local recurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text