Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: A case report and review of the Literature
Autor: | Shannon Morris, Evan S. Dellon, Cherie H. Dunphy, Mark W. Russo, Wozhan Tang |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2006 |
Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment T-cell leukemia Case Report Liver transplantation Gastroenterology Immunophenotyping Fulminant hepatic failure Fatal Outcome Internal medicine hemic and lymphatic diseases Ascites Medicine Humans Leukemia-Lymphoma Adult T-Cell Hepatology medicine.diagnostic_test business.industry Contraindications General Medicine Jaundice Liver Failure Acute Middle Aged medicine.disease Lymphoma Liver Transplantation Killer Cells Natural Leukemia Liver biopsy medicine.symptom business |
Popis: | Acute liver failure (ALF) is a medical emergency requiring immediate evaluation for liver transplantation. We describe an unusual case of a patient who presented with ascites, jaundice, and encephalopathy and was found to have ALF due to natural killer (NK)-like T cell leukemia/lymphoma. The key immunophenotype was CD2+, CD3+, CD7+, CD56+. This diagnosis, which was based on findings in the peripheral blood and ascitic fluid, was confirmed with liver biopsy, and was a contraindication to liver transplantation. A review of the literature shows that hematologic malignancies are an uncommon cause of fulminant hepatic failure, and that NK-like T-cell leukemia/lymphoma is a relatively recently recognized entity which is characteristically CD3+ and CD56+. This case demonstrates that liver biopsy is essential in diagnosing unusual causes of acute liver failure, and that infiltration of the liver with NK-like T-cell lymphoma/leukemia can cause acute liver failure. |
Databáze: | OpenAIRE |
Externí odkaz: |