Super-Resolution Arterial Spin Labeling Using Slice-Dithered Enhanced Resolution and Simultaneous Multi-Slice Acquisition
| Autor: | Danny J.J. Wang, Xingfeng Shao, Qinyang Shou |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Physics
arterial spin label (ASL) MRI simultaneous multi slice General Neuroscience Resolution (electron density) Multi slice Perfusion scanning Neurosciences. Biological psychiatry. Neuropsychiatry super-resolution (SR) slice dithered enhanced resolution (SLIDER) perfusion Tikhonov regularization Arterial spin labeling Singular value decomposition Wafer Dither Neuroscience Original Research Biomedical engineering RC321-571 |
| Zdroj: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience |
| DOI: | 10.3389/fnins.2021.737525/full |
| Popis: | Purpose: To achieve high spatial resolution (isotropic-2 mm) perfusion imaging using 2D simultaneous multi-slice (SMS) pseudo-continuous arterial spin labeling (pCASL) and slice dithered enhanced resolution (SLIDER) technique for super-resolution reconstruction.Methods: The SLIDER-SMS pCASL with a multiband factor of 4 was implemented at 3T with three numbers of slice shift (2/3/4) for the slice thickness of 4/6/8 mm, respectively. Super-resolution reconstruction was performed with singular value decomposition and different levels of Tikhonov regularizations. Temporal and spatial signal-to-noise ratio (SNR) as well as spatial blurring effects of super-resolution ASL images were measured in five healthy subjects and compared with those of reference high-resolution ASL images.Results: Compared to conventional 2D SMS ASL, super-resolution ASL images with isotropic-2-mm resolution yielded 42, 61, and 88% higher spatial SNR, and 18, 55, and 105% higher temporal SNR with slice shift number of 2/3/4, respectively. Spatial blurring effect increased for SLIDER reconstruction from two to four slice shifts.Conclusion: The proposed SLIDER-SMS pCASL technique can achieve whole-brain high-resolution perfusion images with ∼15-min scan time and improved SNR compared to standard 2D SMS pCASL. Caution needs to be exercised on quantifying and controlling blurring effects of SLIDER reconstruction. |
| Databáze: | OpenAIRE |
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