The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
| Autor: | Rong Xiang Chen, Sabine Spijker, Rong Wei Zhai, Zhi Fei Li, Shang Chuan Yang, Yong Mei Sun |
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| Přispěvatelé: | Molecular and Cellular Neurobiology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Narcotics media_common.quotation_subject Spatial Behavior Motor Activity Insular cortex Somatosensory system memory maintenance somatosensory Lesion Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Memory Physiology (medical) Conditioning Psychological medicine Sprague dawley rats Animals Pharmacology (medical) media_common Pharmacology Cerebral Cortex business.industry posterior insula Addiction morphine Original Articles conditioned place preference Conditioned place preference Psychiatry and Mental health 030104 developmental biology nervous system Morphine Original Article medicine.symptom business Insula Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes medicine.drug |
| Zdroj: | CNS Neuroscience and Therapeutics, 24(5), 420-428. Wiley CNS Neuroscience & Therapeutics Sun, Y M, Chen, R X, Li, Z F, Spijker, S, Zhai, R W & Yang, S C 2018, ' The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference ', CNS Neuroscience and Therapeutics, vol. 24, no. 5, pp. 420-428 . https://doi.org/10.1111/cns.12799 |
| ISSN: | 1755-5930 |
| Popis: | Summary The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory‐associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine‐induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine‐induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory. |
| Databáze: | OpenAIRE |
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