Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit
Autor: | Geisla Teles Vieira, Sílvia Dantas Cangussú, Jason G. Taylor, Tânia Toledo de Oliveira, Gabriel Almeida Paes Humberto, Jorge Luiz Humberto, Marco Antonio Alves Carneiro |
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Rok vydání: | 2020 |
Předmět: |
Blood Glucose
Male Equisetum Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alloxan Diabetes mellitus Drug Discovery Hyperlipidemia medicine Animals Hypoglycemic Agents Equisetum giganteum Pancreas 030304 developmental biology Glycated Hemoglobin Pharmacology 0303 health sciences Creatinine biology Traditional medicine Plant Extracts Cholesterol Albumin biology.organism_classification medicine.disease Lipids Liver chemistry Phytochemical 030220 oncology & carcinogenesis Rabbits Biomarkers |
Zdroj: | Journal of Ethnopharmacology. 260:112898 |
ISSN: | 0378-8741 |
Popis: | Ethnopharmacological relevance Equisetum giganteum has been traditionally used as an anti-diabetic herbal remedy to treat diabetes in the southern state of Rio Grande do Sul in Brazil. Aim of the study Considering the ethonopharmacology and historical importance of E. giganteum, its potential antidiabetic effect was evaluated in alloxan induced diabetic rabbits. Material and methods Samples of Equisetum giganteum were collected in the city of Ouro Preto, Minas Gerais, Brazil. Butanolic and aqueous extracts were prepared and subsequently evaluated for anti-diabetic properties in vivo using albino male rabbits. At the end of the treatment period, the animals were euthanized, and histopathological analysis were carried out. The following biochemical parameters were studied: glucose, triacylglycerol, cholesterol, albumin, creatinine, glycosylated hemoglobin and lipase. The phytochemical profile of the extracts was studied by liquid chromatography techniques coupled to a UV/VIS detector and high-resolution mass spectrometry. Results Both aqueous and butanolic extracts were capable of reducing significantly the levels of glucose, cholesterol and triacylglycerol and thus demonstrating their hypolipidemic and hypoglycemiant effects. Furthermore, the extracts prevented the occurrence of hepatic complications during treatment. The phytochemical profile of the extracts was investigated, and the natural products detected were in agreement with those that had been previously described in the literature. Conclusion Based on the significant reductions in biochemical parameters and the histologic evidence for the absence of complications in the liver, pancreas of the treated animals, Equisetum giganteum can be a therapeutically relevant resource in the treatment of diabetes and hyperlipidemia. |
Databáze: | OpenAIRE |
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