Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial
| Autor: | Sandra D. De Silva, Jean Addington, Catherine Marshall, Isabel Domingues, Tyrone D. Cannon, Barbara Walsh, Mary O'Brien, David J. Miklowitz, Jamie Zinberg, Michelle Friedman-Yakoobian, Danielle A. Schlosser, Kristin A. Candan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Family therapy
Male Nonprofessional early warning signs 6.6 Psychological and behavioural medicine.medical_treatment Medical and Health Sciences Education Nonprofessional law.invention Randomized controlled trial law Developmental and Educational Psychology Young adult Problem Solving Pediatric attenuated psychotic symptoms Psychiatry and Mental health Mental Health Treatment Outcome Schizophrenia family therapy Family Therapy Female Family Relations Psychology Psychosocial Social Adjustment Clinical psychology Adult medicine.medical_specialty Pediatric Research Initiative Adolescent Clinical Trials and Supportive Activities Developmental & Child Psychology Education Young Adult Clinical Research Behavioral and Social Science medicine Psychoeducation Humans Bipolar disorder Psychiatry Consumer Health Information Prevention Psychology and Cognitive Sciences Evaluation of treatments and therapeutic interventions medicine.disease Brain Disorders Clinical trial schizophrenia Self Care Good Health and Well Being Psychotic Disorders psychoeducation |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry, vol 53, iss 8 |
| Popis: | ObjectiveLongitudinal studies have begun to clarify the phenotypic characteristics of adolescents and young adults at clinical high risk for psychosis. This 8-site randomized trial examined whether a 6-month program of family psychoeducation was effective in reducing the severity of attenuated positive and negative psychotic symptoms and enhancing functioning among individuals at high risk.MethodAdolescents and young adults (mean age 17.4± 4.1 years) with attenuated positive psychotic symptoms, brief and intermittent psychosis, or genetic risk with functional deterioration were randomly assigned to 18 sessions of family-focused therapy for individuals at clinical high risk (FFT-CHR) in 6 months or 3 sessions of family psychoeducation (enhanced care [EC]). FFT-CHR included psychoeducation about early signs of psychosis, stress management, communication training, and problem-solving skills training, whereas EC focused on symptom prevention. Independent evaluators assessed participants at baseline and 6 months on positive and negative symptoms andsocial-role functioning.ResultsOf 129 participants, 102 (79.1%) were followed up at 6months. Participants in FFT-CHR showed greater improvements in attenuated positive symptoms over 6 months than participants in EC (F1,97= 5.49, p= .02). Negative symptoms improved independently of psychosocial treatments. Changes in psychosocial functioning depended on age: participants more than 19 years of age showed more role improvement inFFT-CHR, whereas participants between 16 and 19 years of age showed more role improvement in EC. The results were independent of concurrent pharmacotherapy.ConclusionInterventions that focus on improving family relationships may have prophylactic efficacy in individuals at high risk for psychosis. Future studies should examine the specificity of effects of family intervention compared to individual therapy of the sameduration and frequency. Clinical trial registration information-Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis; http://clinicaltrials.gov/; NCT01907282. |
| Databáze: | OpenAIRE |
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