Head and neck lipoblastomas: Report of 3 cases and review of the literature
| Autor: | Mohammed Mahtar, Mohammed Laachoubi, Youssef Oukessou, Boutaina Merzouqi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatric
medicine.medical_specialty Myxoid liposarcoma business.industry Case Report Histology medicine.disease Adipose tumor Facial paralysis Benign tumor Lipoblastomatosis 03 medical and health sciences 0302 clinical medicine Cervical mass 030220 oncology & carcinogenesis medicine Genetic predisposition 030211 gastroenterology & hepatology Surgery Lipoblastoma Radiology Differential diagnosis business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| DOI: | 10.1016/j.ijscr.2021.106050 |
| Popis: | Introduction Lipoblastoma is a rare benign tumor arising from embryonic white fat which occurs in the early childhood. It usually arises on the extremities and considered as a rare cause of a pediatric head and neck masses. The aim of this study is to shed light on lipoblastomas as a differential diagnosis of rapidly growing soft fatty masses of children in neck and head area. Patients and methods A retrospective review of 3 patients with lipoblastoma, underwent Surgical resection (case 1 and 2) by cervical approach. The third patient with a facial lipoblastoma was not operated due to the high risk of facial paralysis. Review of literature, diagnostic methods and genetics of lipomatous tumors are discussed. Results Complete surgical excision via a cervical approach demonstrated irregular lobules of immature fat cells separated by a loose, myxoid connective tissue. Histology analysis confirmed the diagnosis of lipoblastoma. Discussion Lipoblastoma is a rare childhood tumor, even rarer in head and neck area. The pathogenesis is unknown, though it is believed to arise from altered embryogenesis of human white fat and genetic predisposition, as chromosome 8 abnormalities may be implicated in the development of lipoblastoma. The presumptive diagnosis is performed by imaging. The most important differential diagnosis of lipoblastoma is myxoid liposarcoma. The mainstay of treatment is complete non-mutilating resection of the tumor to avoid recurrence. Conclusion Lipoblastoma should be suspected in case of heterogeneous fatty tumor in head and neck area, and included as a differential diagnosis of cervical masses in children younger than 3 years. The mainstay of treatment is complete surgical excision with a good prognosis. Highlights • Lipoblastoma should be suspected in case of heterogeneous fatty tumor in head and neck area, in children younger than 3 years. • Otolaryngologist should be familiar with this benign tumor when evaluating soft-tissue mass in the head and neck region. • Complete non-mutilating resection of the tumor is the treatment of choice • clinical follow-up of these lesions is necessary to avoid recurrence and malignant transformation. |
| Databáze: | OpenAIRE |
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