Prognostic classification of breast ductal carcinoma-in-situ
| Autor: | David N. Poller, Melvin J. Silverstein, A. Barth, James R. Waisman, E.D. Gierson, Bernard S. Lewinsky, P. Gamagami, Dennis J. Slamon, W.J. Coburn |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Necrosis medicine.medical_treatment Mammary gland Bone Neoplasms Breast Neoplasms Mastectomy Segmental Disease-Free Survival Ductal carcinoma in situ (DCIS) medicine Comedo Necrosis Carcinoma Humans Prospective Studies skin and connective tissue diseases Prospective cohort study Mastectomy business.industry Carcinoma in situ Carcinoma Ductal Breast General Medicine Prognosis medicine.disease Combined Modality Therapy medicine.anatomical_structure Radiology Neoplasm Recurrence Local medicine.symptom business Carcinoma in Situ |
| Zdroj: | The Lancet. 345:1154-1157 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(95)90982-6 |
| Popis: | We present a new prognostic classification designated the Van Nuys classification for ductal carcinoma-in-situ (DCIS). The classification combines high nuclear grade and comedo-type necrosis to predict clinical recurrence. Three groups of DCIS patients were defined by the presence or absence of high nuclear grade and comedo-type necrosis: 1--non-high-grade DCIS without comedo-type necrosis, 2--non-high-grade DCIS with comedo-type necrosis, 3--high-grade DCIS with or without comedo-type necrosis. There were 31 local recurrences in 238 patients after breast-conservation surgery 3.8% (3/80) in group 1, 11.1% (10/90) in group 2, and 26.5% (18/68) in group 3. The 8-year actuarial disease-free survivals were 93%, 84%, and 61%, respectively (all p < or = 0.05). The Van Nuys classification defines three distinct and easily recognisable groups, each of which has a different likelihood of local recurrence if treated with breast conservation. |
| Databáze: | OpenAIRE |
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