Differing effects of acute and chronic stressors on plasma osteocalcin and leptin in rats

Autor:	P. Patterson-Buckendahl, L. A. Pohorecky, R. Kvetnansky
Rok vydání:	2007
Předmět:	Leptin Male Restraint Physical medicine.medical_specialty Sympathetic nervous system Liquid diet Alcohol Drinking Physiology media_common.quotation_subject Osteocalcin Hierarchy Social Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Corticosterone Internal medicine medicine Animals Ingestion media_common Social stress Behavior Animal biology Endocrine and Autonomic Systems business.industry Appetite Rats Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology medicine.anatomical_structure chemistry biology.protein business Stress Psychological
Zdroj:	Stress. 10:163-172
ISSN:	1607-8888 1025-3890
Popis:	Stressor activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis can have profound effects on bone and also appetite and metabolism. We tested in rats the response of plasma osteocalcin (pOC, a bone biomarker that is acutely stress responsive), corticosterone, and leptin to (1) ethanol consumption (5% w/v) in a liquid diet (compared with ad libitum and pair-fed rats), (2) acute restraint, and (3) acute (once, 1 h) and (4) chronic (1 h/day for 7 weeks) social aggression. Basal pOC concentration did not differ with ethanol diet or social interaction, but was elevated by both foot restraint immobilization (Imo) and restraint in wire mesh cylinders (WMR). As previously reported for chronic Imo, ingestion of ethanol blunted the pOC response to Imo. Plasma corticosterone concentration was increased by acute WMR and acute social interaction but was unaltered by chronic social interaction. Plasma leptin concentration was markedly increased by Imo in ad libitum fed, but only slightly in ethanol or pair-fed rats. In contrast, the data reflect significant differences between acute and chronic stressor effects since chronic social stress had little effect on pOC or plasma corticosterone, but tended to decrease leptin level in relation to dominance. Lack of significant impact of prolonged ethanol intake or social aggression suggests physiological adaptation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe2b9ab50de1edf7aa04b38ed94fcc5 https://doi.org/10.1080/10253890701317601 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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