Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation
| Autor: | Elena Olea, Joana F. Sacramento, Fátima O. Martins, Jesus Prieto-Lloret, Silvia V. Conde, Ana Obeso, Bernardete F. Melo, Paulo Matafome, Emília C. Monteiro, Asunción Rocher |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Fundação para a Ciência e a Tecnologia (Portugal), Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Angiogenesis medicine.medical_treatment Clinical Biochemistry Adipose tissue Inflammation RM1-950 medicine.disease_cause Biochemistry Article 03 medical and health sciences 0302 clinical medicine Insulin resistance SDG 3 - Good Health and Well-being Internal medicine insulin resistance medicine oxidative stress Hypoxia Molecular Biology obstructive sleep apnea metabolic dysfunction business.industry hypoxia Metabolic dysfunction Insulin Cell Biology Hypoxia (medical) medicine.disease Obstructive sleep apnea adipose tissue 030104 developmental biology Endocrinology Oxidative stress inflammation Therapeutics. Pharmacology medicine.symptom business Weight gain 030217 neurology & neurosurgery |
| Zdroj: | Antioxidants, Vol 10, Iss 1233, p 1233 (2021) Digital.CSIC. Repositorio Institucional del CSIC instname Antioxidants Volume 10 Issue 8 Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 2076-3921 2015-7061 |
| Popis: | © 2021 by the authors. Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism. The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017). |
| Databáze: | OpenAIRE |
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