Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Autor:	Christian Bartelmus, Markus Bürkler, Uwe Grether, Christoph Ullmer, Julian Kretz, Irene Knuesel, Ahmed Haider, Roger Schibli, Luca Gobbi, Hazem Ahmed, Linjing Mu, Markus Weber, Adrienne Müller Herde, Kenneth Atz, Michael Honer, Wolfgang Guba, Claudia Keller, Simon M. Ametamey, Jürgen Fingerle, Andreas Brink
Rok vydání:	2019
Předmět:	Male Fluorine Radioisotopes Protein Conformation Pyridines Stereochemistry medicine.medical_treatment Neuroimaging Ligands Receptor Cannabinoid CB2 Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Pyridine Cyclic AMP medicine Animals Humans Structure–activity relationship Rats Wistar Receptor Radiochemistry Molecular Structure medicine.diagnostic_test Brain Rats Mice Inbred C57BL chemistry Positron emission tomography Positron-Emission Tomography Hepatocytes Molecular Medicine lipids (amino acids peptides and proteins) Cannabinoid Radiopharmaceuticals Derivative (chemistry)
Zdroj:	Journal of Medicinal Chemistry. 62:11165-11181
ISSN:	1520-4804 0022-2623
Popis:	The cannabinoid type 2 (CB2) receptor has emerged as a valuable target for therapy and imaging of immune-mediated pathologies. With the aim to find a suitable radiofluorinated analogue of the previously reported CB2 positron emission tomography (PET) radioligand [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdeb6c2cf2905cd5704c6b236a756dd https://doi.org/10.1021/acs.jmedchem.9b01280 Zobrazit plný text záznamu