Theophylline and melanocyte-stimulating hormone: effects on uveal melanocytes of adult rhesus eyes
| Autor: | Kunie Mah, Funan Hu, Dinah J. Teramura |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Melanocyte-stimulating hormone Tyrosinase Dermatology Biology Biochemistry Theophylline Internal medicine medicine Animals Melanocyte-Stimulating Hormones Uvea Molecular Biology Melanosome Cell Biology Macaca mulatta Dihydroxyphenylalanine Microscopy Electron Endocrinology medicine.anatomical_structure Cytochemistry Melanocytes Choroid sense organs medicine.drug Hormone |
| Zdroj: | The Journal of investigative dermatology. 81(2) |
| ISSN: | 0022-202X |
| Popis: | The effects of theophylline and melanocyte-stimulating hormone (MSH) on cultured uveal melanocytes from the eyes of normal adult rhesus macaques were studied by light and electron microscopy and by dopa cytochemistry. The principal effects were changes in melanosome ultrastructure and an increased complexity of Golgi-associated vesicles and cisternae filled with dopa reaction products. The changes were more extensive in iris cells and less remarkable in choroid cells. The effects of theophylline were more pronounced than those of MSH. Our data suggest that normal iridial melanocytes, as do melanogenic murine melanoma cells, respond to theophylline or MSH by increasing tyrosinase synthesis, tyrosinase transfer, and melanization. |
| Databáze: | OpenAIRE |
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