Analysis of 1-(2-phenyladamant-1-yl)-2-methylaminopropane as its chlorodifluoroacetyl derivative
| Autor: | Diana M. Prime, Anthony F. Cockerill, David J. Osborne, D. N. B. Mallen |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Bridged-Ring Compounds
Chromatography Gas Chromatography Aluminium chloride Fluoroacetates Organic Chemistry Diastereomer Adamantane General Medicine Fractionation Biochemistry Analytical Chemistry Antiparkinson Agents chemistry.chemical_compound chemistry medicine Humans Gas chromatography Derivative (chemistry) medicine.drug |
| Zdroj: | Journal of Chromatography A. 114:151-158 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(00)85251-6 |
| Popis: | The diastereoisomeric content of 1-(2-phenyladamant-1-yl)-2-methylaminopropane can be determined by gas chromatography following treatment with chlorodifluoroacetic anhydride. Racemisation occurs in the synthesis of 2-phenyladamantane from the corresponding 2-chloroadamantane in the Friedel-Crafts reaction with aluminium chloride, but fractionation of the diastereoisomers can occure in the purification steps. A method for determining 2-phenyladamantane in plasma and urine extracts at the nanogram level using an electron-capture detector is described and compared with a previously described radio-assay procedure. |
| Databáze: | OpenAIRE |
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