Liver biopsy performance and histological findings among patients with chronic viral hepatitis:a Danish database study
| Autor: | Peer Brehm Christensen, Henrik Bygum Krarup, Axel Møller, Alex Lund Laursen, Mette S. Kjaer, Marianne Orholm, Jens Lindberg, Karin Groenbaek, Hans Kromann-Andersen, Nina Weis, null THE DANHEP GROUP |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Adult Liver Cirrhosis Male medicine.medical_specialty Pathology HBsAg Cirrhosis Biopsy Denmark Gastroenterology Hepatitis B Chronic Internal medicine medicine Humans Registries General Immunology and Microbiology biology medicine.diagnostic_test business.industry Alanine Transaminase General Medicine Hepatitis C Hepatitis B Hepatitis C Chronic Middle Aged medicine.disease Infectious Diseases Logistic Models Alanine transaminase Liver biopsy biology.protein Female business Viral hepatitis |
| Zdroj: | Christensen, P B, Krarup, H B, Møller, A, Laursen, A L, Kjaer, M S, Orholm, M, Lindberg, J, Groenbaek, K, Kromann-Andersen, H, Weis, N & Group, D 2007, ' Liver biopsy performance and histological findings among patients with chronic viral hepatitis : a Danish database study ', Scandinavian Journal of Infectious Diseases, vol. 39, no. 3, pp. 245-249 . https://doi.org/10.1080/00365540600978864 Brehm Christensen, P, Krarup, H B, Møller, A, Laursen, A L, S. Kjaer, M, Orholm, M, Lindberg, J, Groenbaek, K, Kromann-Andersen, H, Weis, N & DANHEP Group, T 2007, ' Liver biopsy performance and histological findings among patients with chronic viral hepatitis : A Danish database study ', Scandinavian Journal of Infectious Diseases, vol. 39, no. 3, pp. 245-249 . |
| Popis: | We investigated the variance of liver biopsy frequency and histological findings among patients with chronic viral hepatitis attending 10 medical centres in Denmark. Patients who tested positive for HBsAg or HCV- RNA were retrieved from a national clinical database (DANHEP) and demographic data, laboratory analyses and liver biopsy results were collected. A total of 1586 patients were identified of whom 69.7% had hepatitis C, 28.9% hepatitis B, and 1.5% were coinfected. In total, 771 (48.6%) had a biopsy performed (range 33.3-78.7%). According to the Metavir classification, 29.3% had septal fibrosis (> or =F2) and 13.9% had cirrhosis (F4). The frequency of cirrhosis varied from 8.3 to 18.6% among centres, and was independently associated with age, male gender, elevated alanine-aminotransferase (ALT) and non-Danish origin. Among 141 patients with hepatitis C and known duration of infection, cirrhosis had developed in 23% after 20 y of infection. Age above 40 y was a better predictor of cirrhosis than elevated ALT. National database comparison may identify factors of importance for improved management of patients with chronic viral hepatitis. |
| Databáze: | OpenAIRE |
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