Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
| Autor: | Hiroyuki Tsuda, Hiromi Kushida, Minako Nagao, Keiji Wakabayashi, Michio Mori, Katsuhiko Enomoto, Noritoshi Takeichi, Takashi Sugimura, Hideko Sone |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Normal diet Hepatocellular carcinoma Article Liver Neoplasms Experimental Quinoxalines Internal medicine medicine Carcinoma Animals Carcinogen chemistry.chemical_classification Hepatitis Dose-Response Relationship Drug biology Body Weight Alanine Transaminase Rats Inbred Strains Organ Size HCCS LEC rat medicine.disease Rats Endocrinology Liver Oncology chemistry Alanine transaminase MeIQx Heterocyclic amine Carcinogens biology.protein Copper |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1996.tb00195.x |
| Popis: | A food-borne heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), induces hepatocellular carcinomas (HCCs) in F344 male rats at an incidence of 95%, when fed in the diet at 400 ppm for 61 weeks. In this study, the effect of a low dose of MeIQx was examined in Long-Evans with cinnamon-like coat color (LEC) rats, which have a mutation in Atp7b and suffer from hereditary hepatitis and HCCs, with high levels of copper accumulation in the liver. Rats of the LEC and Long-Evans with agouti coat color (LEA) sibling lines were given a diet containing 40 ppm MeIQx from the age of 23 weeks to 63 weeks, for a total administration period of 40 weeks. In LEC rats, HCCs were observed in 8/8 animals administered MeIQx, and 2/8 rats receiving a normal diet. The number of HCCs per rat (mean +/- SD) was 2.8 +/- 2.0 and 0.3 +/- 0.5, respectively. In the LEA rats, however, no tumors were induced by administration of MeIQx. These results indicate that damaged liver associated with compensatory cell proliferation is much more susceptible to chemical hepatocarcinogens, including MeIQx, than the normal liver. |
| Databáze: | OpenAIRE |
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