99mTc-Methionine Hybrid SPECT/CT for Detection of Recurrent Glioma
| Autor: | Anshul Sharma, Ajay Garg, Puja Panwar Hazari, Deepak Aheer, Ahitagni Biswas, Punit Sharma, Anil K. Mishra, Rakesh Kumar, Geetanjali Arora |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Single Photon Emission Computed Tomography Computed Tomography CONTRAST ENHANCED MRI Recurrent Glioma Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Methionine 0302 clinical medicine Text mining Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Glioma medicine Humans Radiology Nuclear Medicine and imaging neoplasms Brain Neoplasms business.industry Technetium General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Tumor recurrence chemistry 030220 oncology & carcinogenesis Female Fdg pet ct Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | Clinical Nuclear Medicine. 43:e132-e138 |
| ISSN: | 1536-0229 0363-9762 |
| DOI: | 10.1097/rlu.0000000000002036 |
| Popis: | Posttherapy changes in treated glioma patients cannot be reliably differentiated from tumor recurrence. We evaluated the role of Tc-methionine SPECT/CT for the detection of recurrent glioma and compared the same with F-FDG PET/CT and contrast-enhanced MRI (CeMRI).Forty-four patients with histologically proven, previously treated glioma and clinical suspicion of recurrence were prospectively enrolled in the study. Of these 44 patients, 39 (28 male and 11 female subjects; age, 38.05 ± 9.7 years) underwent Tc-methionine SPECT/CT, F-FDG PET/CT, and CeMRI of the brain and were included for final analysis. Combination of repeat imaging, biopsy, and/or clinical follow-up (6-36 months) was taken as reference standard. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. Diagnostic values among modalities were compared.Positive predictive value and negative predictive value for Tc-methionine SPECT/CT, F-FDG PET/CT, and CeMRI were 95.6% and 56.2%, 92.3% and 61.5%, and 79.4% and 42.9%, respectively. Sensitivity and specificity for the 3 modalities were 75.9% and 90%, 82.8% and 80%, and 87.1% and 30%. Specificity of Tc-methionine SPECT/CT was significantly higher than that of CeMRI (P0.0001) but not of F-FDG PET/CT (P = 0.36). No significant difference was seen between the modalities for sensitivity and accuracy.Tc-methionine is a promising tracer for detection of recurrent glioma. Diagnostic values of Tc-methionine SPECT/CT are similar to F-FDG, although it is more specific than CeMRI. So it may be used as a cost-effective alternative and also where PET/CT is not available. |
| Databáze: | OpenAIRE |
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