Effect of antihypertensive treatment on the long-term outcome of patients discharged after acute ischemic stroke
Autor: | Marianna Spanou, Konstantinos Tziomalos, Stella-Maria Angelopoulou, Stavroula Kostaki, Christos Savopoulos, Vasilios Giampatzis, Eleni Margariti, Apostolos I. Hatzitolios, Maria Papadopoulou, Stella D. Bouziana |
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Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Health Status Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology Lower risk Brain Ischemia Angiotensin Receptor Antagonists 03 medical and health sciences 0302 clinical medicine Modified Rankin Scale Internal medicine Internal Medicine Humans Medicine Binary logistic regression analysis Mortality Diuretics Stroke Acute ischemic stroke Antihypertensive Agents Aged Aged 80 and over business.industry General Medicine Calcium Channel Blockers medicine.disease Patient Discharge Confidence interval Relative risk Hypertension Physical therapy Female Angiotensin Receptor Blockers business 030217 neurology & neurosurgery |
Zdroj: | Clinical and Experimental Hypertension. 39:246-250 |
ISSN: | 1525-6006 1064-1963 |
Popis: | We aimed to evaluate the effects of the five main classes of antihypertensive agents on the long-term outcome of 313 consecutive patients discharged after acute ischemic stroke (36.4% males, age 78.5 ± 6.3 years). One year after discharge, the functional status [evaluated with the modified Rankin scale (mRS)], the occurrence of cardiovascular events, and vital status were recorded. Patients prescribed angiotensin receptor blockers (ARBs) had lower mRS than patients not prescribed ARBs (1.7 ± 2.0 vs. 2.9 ± 2.5, respectively; p = 0.006). The rates of adverse outcome (mRS 2-6) and cardiovascular events did not differ between patients prescribed each one of the major classes of antihypertensive agents and those not prescribed the respective class. Patients who were prescribed ARBs had lower risk of death during follow-up than patients who did not receive ARBs (9.4 and 26.9%, respectively; p < 0.05). In binary logistic regression analysis, the only independent predictor of all-cause mortality during follow-up was the mRS at discharge (relative risk 1.69, 95% confidence interval 1.25-2.28; p < 0.001). In conclusion, in patients discharged after acute ischemic stroke, administration of ARBs appears to have a more beneficial effect on long-term functional outcome and all-cause mortality than treatment with other classes of antihypertensive agents. |
Databáze: | OpenAIRE |
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