Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes
| Autor: | Andrea I. Loaiza-Pérez, Jonathan V. Wooten, Melissa Davis, Nicole Mavingire, Petreena Campbell, Eileen Brantley, Joyce Aja |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Antineoplastic Agents Hormonal Receptor ErbB-2 medicine.medical_treatment Breast Neoplasms Article Targeted therapy 03 medical and health sciences 0302 clinical medicine Breast cancer DISPARITIES Cancer stem cell BREAST CANCER medicine Humans Fulvestrant Protein kinase B PI3K/AKT/mTOR pathway ENDOCRINE THERAPY business.industry purl.org/becyt/ford/3.1 [https] medicine.disease ENDOCRINE RESISTANCE 030104 developmental biology Receptors Estrogen Oncology Hypoxia-inducible factors Drug Resistance Neoplasm Hormone receptor 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research Female purl.org/becyt/ford/3 [https] Neoplasm Recurrence Local Stem cell business Proto-Oncogene Proteins c-akt Signal Transduction STEM CELLS |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Cancer Lett |
| Popis: | Breast cancer stem cells (BCSCs) promote endocrine therapy (ET) resistance, also known as endocrine resistance in hormone receptor (HR) positive breast cancer. Endocrine resistance occurs via mechanisms that are not yet fully understood. In vitro, in vivo and clinical data suggest that signaling cascades such as Notch, hypoxia inducible factor (HIF), and integrin/Akt promote BCSC-mediated endocrine resistance. Once HR positive breast cancer patients relapse on ET, targeted therapy agents such as cyclin dependent kinase inhibitors are frequently implemented, though secondary resistance remains a threat. Here, we discuss Notch, HIF, and integrin/Akt pathway regulation of BCSC activity and potential strategies to target these pathways to counteract endocrine resistance. We also discuss a plausible link between elevated BCSC-regulatory gene levels and reduced survival observed among African American women with basal-like breast cancer which lacks HR expression. Should future studies reveal a similar link for patients with luminal breast cancer, then the use of agents that impede BCSC activity could prove highly effective in improving clinical outcomes among African American breast cancer patients. Fil: Mavingire, Nicole. Loma Linda University Health School of Medicine; Estados Unidos Fil: Campbell, Petreena. Loma Linda University Health School of Medicine; Estados Unidos Fil: Wooten, Jonathan. Loma Linda University Health School of Medicine; Estados Unidos Fil: Aja, Joyce. University of the Philippines Diliman; Filipinas Fil: Davis, Melissa B. New York Presbyterian Hospital; Estados Unidos Fil: Loaiza Perez, Andrea Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Brantley, Eileen. Loma Linda University Health School of Medicine; Estados Unidos |
| Databáze: | OpenAIRE |
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