Evaluation of neuroendocrine tumors with 99mTc-EDDA/HYNIC TOC
| Autor: | Jelena Petrovic, Marina Vlajkovic, Aida Afgan, Dragana Sobic-Saranovic, Vladimir Obradović, Nebojša Petrović, Branislava Radović, Vera Artiko |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Peptide receptor Octreotide Neuroendocrine tumors Scintigraphy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Humans Medicine False Positive Reactions Radiology Nuclear Medicine and imaging Neoplasm Metastasis False Negative Reactions Edetic Acid Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Organotechnetium Compounds General Medicine Middle Aged medicine.disease Predictive value 3. Good health Neuroendocrine Tumors True negative 030220 oncology & carcinogenesis Radionuclide therapy Female Radiology business Nuclear medicine medicine.drug |
| Zdroj: | Nuclear Medicine Review. 19:99-103 |
| ISSN: | 1644-4345 1506-9680 |
| DOI: | 10.5603/nmr.2016.0020 |
| Popis: | BACKGROUND: This paper is the short review of our preliminary results obtained with 99mTc-EDDA/HYNIC-TOC. MATERIAL AND METHODS: The total of 495 patients with different neuroendocrine tumors were investigated during last few years. RESULTS: There have been 334 true positive (TP), 73 true negative (TN), 6 false positive (FP) and 82 false negative findings (FN). Diagnosis was made according to SPECT findings in 122 patients (25%). The mean T/NT ratio for TP cases was significantly higher (p < 0.01) on SPECT (3.12 ± 1.13) than on whole body scan (2.2 ± 0.75). According to our results, overall sensitivity of the method is 80%, specificity 92%, positive predictive value 98%, negative predictive value 47% and accuracy 82%. Fifteen TP patients underwent therapy with 90Y-DOTATATE. CONCLUSION: Scintigraphy of neuroendocrine tumors with 99mTc-Tektrotyd is a useful method for diagnosis, staging and follow up of the patients suspected to have neuroendocrine tumors. SPECT had important role in diagnosis. It is also helpful in the appropriate choice of the therapy, including the peptide receptor radionuclide therapy. In the absence of 68Ga-labeled peptides and PET/CT, the special emphasize should be given to application of SPECT/CT as well as to the radioguided surgery. |
| Databáze: | OpenAIRE |
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