LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
| Autor: | Meriem Tazir, Pierre Pollak, Anne-Louise Leutenegger, Sabine Janin, Alexandra Durr, Ebba Lohmann, Alexis Brice, Suzanne Lesage |
|---|---|
| Přispěvatelé: | Neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Neurologie, CHU Mustapha, Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Levodopa
Pathology medicine.medical_specialty Heterozygote Parkinson's disease MESH: Mutation MESH: Africa Northern Substantia nigra Disease Protein Serine-Threonine Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 MESH: Protein-Serine-Threonine Kinases 03 medical and health sciences 0302 clinical medicine Africa Northern medicine Humans Resting tremor ComputingMilieux_MISCELLANEOUS 030304 developmental biology MESH: Heterozygote 0303 health sciences MESH: Humans MESH: Middle Aged business.industry Dopaminergic Homozygote Parkinson Disease General Medicine Middle Aged medicine.disease LRRK2 humanities nervous system diseases Arabs nervous system Mutation MESH: Arabs North african [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] business Neuroscience 030217 neurology & neurosurgery MESH: Parkinson Disease medicine.drug MESH: Homozygote |
| Zdroj: | New England Journal of Medicine New England Journal of Medicine, Massachusetts Medical Society, 2006, 354 (4), pp.422-3. ⟨10.1056/NEJMc055540⟩ New England Journal of Medicine, 2006, 354 (4), pp.422-3. ⟨10.1056/NEJMc055540⟩ |
| ISSN: | 0028-4793 1533-4406 |
| DOI: | 10.1056/NEJMc055540⟩ |
| Popis: | To the Editor: Parkinson's disease is characterized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, a good response to levodopa, an... |
| Databáze: | OpenAIRE |
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