Cardiovascular effects of diazepam and chlordiazepoxide
| Autor: | Herman B. Daniell |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Cardiac output
Hemodynamics Blood Pressure Hexamethonium Compounds Chlordiazepoxide Coronary circulation Hexamethonium compound Dogs Oxygen Consumption Heart Rate Coronary Circulation Heart rate medicine Animals Cardiac Output Phentolamine Aorta Practolol Pharmacology Diazepam business.industry Myocardial Contraction Blood pressure medicine.anatomical_structure Regional Blood Flow Anesthesia business medicine.drug |
| Zdroj: | European journal of pharmacology. 32(1) |
| ISSN: | 0014-2999 |
| Popis: | In open-chest dog preparations i.v. administration of diazepam and chlordiazepoxide caused increases in coronary blood flow and cardiac output while reducing blood pressure, heart rate, and myocardial contractile force. The decrease in force was independent of the alteration in coronary flow. Arterial--coronary sinus oxygen difference narrowed and myocardial oxygen consumption decreased. These data show that both diazepam and chlordiazepoxide exert an oxygen conserving action along with an increase in myocardial oxygen delivery and suggest that these drugs may be of benefit to the patient with coronary insufficiency by a direct effect on the cardiovascular system as well as through CNS-mediated antianxiety effects. |
| Databáze: | OpenAIRE |
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