Optimal Approach to Circumferential Decompression and Reconstruction for Thoracic Spine Metastatic Disease

Autor: Matthew R. Sanborn, Jessica Ou, Anna Zhu, Jennifer Kosty, Theodore W. Mooncai, Ali Bernstein, Jonathan M. Bekisz, Thomas M. Neustein, Neil R. Malhotra, Sherman C. Stein
Rok vydání: 2014
Předmět:
Zdroj: Annals of Surgical Oncology. 21:2864-2872
ISSN: 1534-4681
1068-9265
DOI: 10.1245/s10434-014-3685-7
Popis: Circumferential decompression has been demonstrated to be the first-line therapy for patients with metastatic tumors in the thoracic spine requiring surgical intervention. However, there is significant debate regarding whether these tumors are best accessed anteriorly utilizing a thoracotomy or posteriorly. We used decision analysis to determine which approach yields greater health-related quality of life (QOL). We searched Medline, Embase, and the Cochrane Library for relevant articles published between 1990 and 2011 on anterior and posterior approaches to metastatic disease in the thoracic spine. QOL values for major treatment outcomes were determined using the existing literature. Separate models were created for ambulatory and nonambulatory patients. A Monte Carlo simulation and sensitivity analyses were used to determine which treatment strategy resulted in the highest QOL. For ambulatory patients, an anterior approach resulted in a slightly higher QOL, and for nonambulatory patients, a posterior approach was favored, but these differences were not statistically significant. Using a decision-analytic model, we found no significant difference in QOL resulting from anterior versus posterior approaches to metastatic lesions in the thoracic spine. Decisions should instead be based on surgeon comfort, tumor characteristics, anatomy of the lesion, patient-related factors, and goals of the operation.
Databáze: OpenAIRE
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