The therapeutic and prognostic implications of immunobiology in colorectal cancer: a review
| Autor: | Des C. Winter, Alexandra M Zaborowski, Lydia Lynch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment Disease Review Article medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immune system Antineoplastic Agents Immunological Lymphocytes Tumor-Infiltrating Internal medicine medicine Tumor Microenvironment Humans Precision Medicine Tumor biology business.industry medicine.disease Prognosis Disease control Radiation therapy 030104 developmental biology Microsatellite Stable 030220 oncology & carcinogenesis Tumour immunology Immunotherapy Carcinogenesis business Colorectal Neoplasms |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Colorectal cancer represents the second leading cause of cancer-related death worldwide. The therapeutic field of immuno-oncology has rapidly gained momentum, with strikingly promising results observed in clinical practice. Increasing emphasis has been placed on the role of the immune response in tumorigenesis, therapy and predicting prognosis. Enhanced understanding of the dynamic and complex tumour-immune microenvironment has enabled the development of molecularly directed, individualised treatment. Analysis of intra-tumoural lymphocyte infiltration and the dichotomisation of colorectal cancer into microsatellite stable and unstable disease has important therapeutic and prognostic implications, with potential to capitalise further on this data. This review discusses the latest evidence surrounding the tumour biology and immune landscape of colorectal cancer, novel immunotherapies and the interaction of the immune system with each apex of the tripartite of cancer management (oncotherapeutics, radiotherapy and surgery). By utilising the synergy of chemotherapeutic agents and immunotherapies, and identifying prognostic and predictive immunological biomarkers, we may enter an era of unprecedented disease control, survivorship and cure rates. |
| Databáze: | OpenAIRE |
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