Investigation of an inflammatory humoral factor as a stimulator of fibrinogen synthesis
| Autor: | T. Roy Ittyerah, Noel Weidner, Laurence A. Sherman, R. Dean Wochner |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cell Extracts
Male medicine.medical_specialty Lysine Inflammation Fibrinogen chemistry.chemical_compound Plasma Mediator Peritoneum Internal medicine medicine Leukocytes Animals Blood Transfusion Serum Albumin Glycogen Albumin Acute-phase protein Hematology medicine.anatomical_structure Endocrinology Biochemistry chemistry Rabbits medicine.symptom medicine.drug |
| Zdroj: | Thrombosis research. 15(5-6) |
| ISSN: | 0049-3848 |
| Popis: | A purported stimulatory effect on fibrinogen synthesis of pyrogenic crude leukocyte extract (CLE) is controversial. To clarify this issue, a study was made of possible inflammatory cellular or humoral factors as stimulators of fibrinogen synthesis. Relative fibrinogen synthesis ratios were calculated by comparing the rate of incorporation of radiolabeled lysine into fibrinogen with that of incorporation into albumin. Significant increases in the ratio over baseline values were observed in rabbits after i. v. administration of CLE derived from 0.99 – 3. 35×109 homologous leukocytes harvested from inflammed rabbit peritoneal cavities (0.146±0.038 control and 0.249±0.119 after CLE, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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