Impaired arginine–vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor
| Autor: | Masami Hiroyama, Yoko Fujiwara, Toshinori Aoyagi, Atsushi Sanbe, Akito Tanoue, Jun-ichi Birumachi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Receptors Vasopressin medicine.medical_specialty Vasopressin medicine.drug_class Neuropeptide Adrenocorticotropic hormone Mice chemistry.chemical_compound Adrenocorticotropic Hormone Internal medicine Adrenal Glands medicine Animals RNA Messenger Receptor Aldosterone Cells Cultured Vasopressin receptor Mice Knockout Pharmacology Adrenal gland Arginine Vasopressin Endocrinology medicine.anatomical_structure chemistry Mineralocorticoid hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Pharmacology. 566:226-230 |
| ISSN: | 0014-2999 |
| Popis: | We examined aldosterone release in response to stimulation with arginine–vasopressin (AVP) using adrenal gland cells. AVP caused a significant increase in aldosterone release from the dispersed adrenal gland cells of wild-type mice (V 1A R +/+ ) at concentrations from 0.1 μM to 1 μM. In contrast, AVP-induced aldosterone release was impaired in adrenal gland cells from mice lacking the vasopressin V 1A receptor (V 1A R −/− ), while adrenocorticotropic hormone (ACTH)-induced aldosterone release in V 1A R −/− mice was not significantly different from that in V 1A R +/+ mice. In addition, a vasopressin V 1A receptor-selective antagonist 1-[1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydro-2(1 H )-quinolinone (OPC-21268) potently inhibited AVP-induced aldosterone release. Thus, our study clearly demonstrates that AVP-induced aldosterone release from adrenal gland cells is mediated via the vasopressin V 1A receptor in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect