Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection

Autor: Judith S. Currier, Julian Falutz, Steven K. Grinspoon, Grace A. McComsey, Giovanni Guaraldi, J. Capeau, Esteban Martínez, Fred R. Sattler, Takara L. Stanley, Shalendar Bhasin, Michael P. Dubé, Todd T. Brown, Kristine M. Erlandson, Jordan E. Lake, Caroline M. Apovian
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
obesity
Human immunodeficiency virus (HIV)
HIV Infections
Disease
medicine.disease_cause
Medical and Health Sciences
0302 clinical medicine
Risk Factors
2.2 Factors relating to the physical environment
2.1 Biological and endogenous factors
030212 general & internal medicine
Aetiology
Adiposity
education.field_of_study
human immunodeficiency virus
HIV-Associated Lipodystrophy Syndrome
virus diseases
Disease Management
Biological Sciences
Generalized obesity
Infectious Diseases
antiretroviral therapy
HIV/AIDS
Female
Infection
Microbiology (medical)
medicine.medical_specialty
Anti-HIV Agents
Population
Microbiology
Management of obesity
03 medical and health sciences
Clinical Research
Major Article
medicine
Humans
Highly Active
lipohypertrophy
Intensive care medicine
education
Metabolic and endocrine
Nutrition
business.industry
Prevention
Lipohypertrophy
medicine.disease
030112 virology
Antiretroviral therapy
Virology
Obesity
CD4 Lymphocyte Count
Good Health and Well Being
business
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 64, iss 10
ISSN: 1537-6591
1058-4838
DOI: 10.1093/cid/cix178
Popis: Background Obesity and lipohypertrophy are common in treated human immunodeficiency virus (HIV) infection and contribute to morbidity and mortality among HIV-infected adults on antiretroviral therapy (ART). Methods We present a consensus opinion on the diagnosis, clinical consequences, and treatment of excess adiposity in adults with treated HIV infection. Results Obesity and lipohypertrophy commonly occur among HIV-infected adults on ART and may have overlapping pathophysiologies and/or synergistic metabolic consequences. Traditional, HIV-specific, and ART-specific risk factors all contribute. The metabolic and inflammatory consequences of excess adiposity are critical drivers of non-AIDS events in this population. Although promising treatment strategies exist, further research is needed to better understand the pathophysiology and optimal treatment of obesity and lipohypertrophy in the modern ART era. Conclusions Both generalized obesity and lipohypertrophy are prevalent among HIV-infected persons on ART. Aggressive diagnosis and management are key to the prevention and treatment of end-organ disease in this population and critical to the present and future health of HIV-infected persons.
Databáze: OpenAIRE
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