Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens
| Autor: | Robert J. Moore, Mark M Williamson, Milena M. Awad, Anthony L. Keyburn, Scott A Sheedy, Julian I. Rood, Mark E Ford |
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| Rok vydání: | 2006 |
| Předmět: |
animal structures
Clostridium perfringens Virulence Factors Bacterial Toxins Immunology Virulence medicine.disease_cause Microbiology Virulence factor Enteritis Pathogenesis Necrosis Immunity medicine Animals Humans Clostridiaceae biology Toxin Calcium-Binding Proteins biology.organism_classification medicine.disease Molecular Pathogenesis Virology Infectious Diseases Type C Phospholipases embryonic structures Parasitology Chickens |
| Zdroj: | Infection and Immunity. 74:6496-6500 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00806-06 |
| Popis: | The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens. |
| Databáze: | OpenAIRE |
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