miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5
| Autor: | Wan Joo Chun, Hua Zou, Jin-Won Lee, Wei Guan, Heasung Kim, Huiling Cui, Ping Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Article Subject business.industry Cell Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease medicine.disease_cause Epithelium 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology Cell culture 030220 oncology & carcinogenesis microRNA medicine Cancer research Biomarker (medicine) Mir 200c Ovarian cancer Carcinogenesis business RC254-282 Research Article |
| Zdroj: | Journal of Oncology, Vol 2020 (2020) Journal of Oncology |
| ISSN: | 1687-8450 |
| DOI: | 10.1155/2020/3404059 |
| Popis: | Ovarian cancer is the second most common gynaecological malignancy, and microRNAs (miRNAs) play important role in the cancer development. Here, we found that the level of miR-200b/200a/429 was significantly increased in serum and tumor tissues of patients with stage-I ovarian cancer. Consistent with these results, we detected increased expression levels of miR-200b/200a/429 in ovarian cancer cell lines compared with the human nontumorigenic ovarian epithelial cell line T80. The overexpression of miR-200b/200a/429 in T80 cells stimulated proliferation and caused their growth in soft agar and tumor formation in nude mice. Furthermore, we determined that miR-200b/200a/429 targets inhibitor of growth family 5 (ING5) and that the overexpression of ING5 can block miR-200b/200a/429-induced T80 cell transformation and tumorigenesis. Our findings suggest that miR-200b/200a/429 may be a useful biomarker for the early detection of ovarian cancer and that miR-200b/200a/429 significantly contributes to ovarian cancer development through ING5. |
| Databáze: | OpenAIRE |
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