Guineensine, an Acyl-CoA: Cholesterol Acyltransferase Inhibitor, from the Fruits ofPiper longum

Autor:	Jung Yeon Nam, Oh Eok Kwon, Mun-Chual Rho, Eun Hee Lim, Young Kook Kim, Hyun Sun Lee, Young Ho Kim, Seung Woong Lee
Rok vydání:	2004
Předmět:	Stereochemistry Sterol O-acyltransferase Pharmaceutical Science Alkenes Pharmacognosy Heterocyclic Compounds 2-Ring Analytical Chemistry Drug Discovery Animals Enzyme Inhibitors Pharmacology chemistry.chemical_classification Piper biology Plant Extracts Organic Chemistry Biological activity Piperaceae biology.organism_classification Rats Enzyme Liver Complementary and alternative medicine chemistry Biochemistry Acyltransferases Enzyme inhibitor Fruit Microsomes Liver biology.protein Molecular Medicine Phytotherapy Sterol O-Acyltransferase
Zdroj:	Planta Medica. 70:678-679
ISSN:	1439-0221 0032-0943
DOI:	10.1055/s-2004-827193
Popis:	Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd12b5a9d2d2d266bb9c58e39e39f68 https://doi.org/10.1055/s-2004-827193 Zobrazit plný text záznamu