Preoperative alkaline phosphatase elevation was associated with poor survival in colorectal cancer patients
| Autor: | Pao-Shiu Hsieh, Jinn-Shiun Chen, Chien-YuhYeh, Reiping Tang, Jeng-Fu You, Hsin-Yuan Hung, Yau-Tong You, Jy-Ming Chiang, Wen-SyTasi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Time Factors Cirrhosis Bilirubin Colorectal cancer Kaplan-Meier Estimate Adenocarcinoma Gastroenterology 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Carcinoembryonic antigen Predictive Value of Tests Risk Factors Internal medicine Biomarkers Tumor medicine Humans Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies biology business.industry Cancer Middle Aged Hepatology Alkaline Phosphatase medicine.disease Up-Regulation Treatment Outcome 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein Alkaline phosphatase Female Colorectal Neoplasms business |
| Zdroj: | International Journal of Colorectal Disease. 32:1775-1778 |
| ISSN: | 1432-1262 0179-1958 |
| Popis: | Purpose To assess preoperative serum alkaline phosphatase (ALP) levels in colon adenocarcinomapatients with various clinical features and determine its prognostic value. Between 2000 and 2013, 10,800 stage I-IV colon cancer patients who underwent surgery wereretrospectively enrolled. The relationship between ALP level and variables, including age, gender,carcinoembryonic Antigen (CEA) levels, aspartate aminotransferase (AST) level, bilirubin level, tumor size,liver cirrhosis, hepatitis, albumin level, histological type, and TNM-stage, were evaluated. The impact of ALP level elevation on survival was evaluated. Significant elevations in ALP level were found in patients with CEA ≥5 ng/ml (p |
| Databáze: | OpenAIRE |
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