Pharmacological evaluation ofPotentilla albaL. in mice: adaptogenic and central nervous system effects
| Autor: | Maria A Lazukina, Marina N. Makarova, Olga N. Pozharitskaya, Valery G. Makarov, Alexander N. Shikov, Olga V Golubeva, GI Djachuk |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Central Nervous System Male Photoperiod Drug Evaluation Preclinical Pharmaceutical Science Context (language use) Drug Administration Schedule law.invention Mice Oral administration law Adaptation Psychological Drug Discovery Potentilla Rhodiola Animals Lactic Acid Swimming Pharmacology Mice Inbred BALB C Behavior Animal Dose-Response Relationship Drug biology Traditional medicine Plant Extracts Body Weight General Medicine biology.organism_classification Rhizome Disease Models Animal Dose–response relationship Rhodiola rosea Anti-Anxiety Agents Complementary and alternative medicine Molecular Medicine Phytotherapy Glycogen |
| Zdroj: | Pharmaceutical Biology. 49:1023-1028 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.3109/13880209.2011.560162 |
| Popis: | Potentilla alba L. (Rosaceae) rhizomes have anti-inflammatory, antioxidant, and adaptogenic effects and are used for the treatment of diarrhea and intestinal colic. However, the data concerning the adaptogenic and central nervous system activities of P. alba are fragmentary.To determine the effect of oral administration of dried P. alba extract on the swimming endurance, light/dark exploration, and open-field tests for mice.The mice were orally administered Rhodiola rosea extract (RR group); dry extract of P. alba at doses of 12, 36, or 72 mg/kg (groups: PA12, PA36, and PA72); or distilled water (control group) for 7 consecutive days.The swimming times of the RR, PA36, and PA72 groups were significantly longer than those of the control group. The administration of P. alba significantly increased the light time, latency time, and the number of rearings in a dose-dependent manner. In the open-field test, the P. alba extract at a dose of 12 mg/kg produced a significant increase in the frequency of head dipping and the number of squares crossed and a significant decrease in grooming compared with the control treatment.The current findings demonstrate that P. alba extracts significantly increased swimming endurance time and have anxiolytic-like action with a predominant locomotor component. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |