Role of Lysosomes and Cathepsin Inhibitor in Plasma during Pneumococcal Infection
| Autor: | Bernard F. Morrey, Henry B. Kirby, Kathryn Haden, James C. Guckian |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
Shwartzman phenomenon Antimetabolites Pneumococcal Infections Microbiology Pathogenesis Sepsis medicine Animals Immunology and Allergy Mechlorethamine Cardiac Output Pyruvates Pancreatic elastase Cathepsin chemistry.chemical_classification Pancreatic Elastase Chemistry Muscles Myocardium Hydrogen-Ion Concentration medicine.disease Cathepsins Metabolic pathway Pneumococcal infections Infectious Diseases Enzyme Liver Immunology Rabbits Lysosomes Agranulocytosis Shwartzman Phenomenon |
| Zdroj: | Journal of Infectious Diseases. 122:290-302 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/122.4.290 |
| Popis: | Infecting microorganisms may directly affect metabolic processes by competition for substrate or they may release toxins which may affect specific metabolic pathways. Alternatively, substances causing an adverse effect upon biochemical mechanisms may be released by the host in response to infection. Since DeDuve and his associates described lysosomes [1], many workers have attributed a major role to acid hydrolases in inflammatory and toxic phenomena. It has been postulated that bacterial lipopolysaccharides, acidosis of tissues, and hypoxia disrupt lysosomes; the ensuing release of acid hydrolases then alters cellular metabolism and causes cellular death [2-4]. However, the role of lysosomes and lysosomal enzymes in the pathogenesis of infection is unknown. The following studies were designed to determine the role of lysosomes and their enzymes in the pathogenesis of lethal pneumococcal infection. |
| Databáze: | OpenAIRE |
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