Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF
| Autor: | Cetin, G.Y., Balkarli, A., Öksüz, A.N., Kimyon, G., Pehlivan, Y., Orhan, O., Kisacik, B., Çobankara, Veli, Sayarlioglu, H., Onat, A.M., Sayarlioglu, M. |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
onset age
Adult Male Tratamento Beck Depression Inventory Drug Resistance complication Familial Mediterranean fever patient compliance colchicine Article leg pain familial Mediterranean fever Humans controlled study human Prospective Studies General Environmental Science amyloidosis child Depression medication compliance abdominal pain thorax pain school child major clinical study clinical feature Resistência à Colchicina Treatment hematuria Colchicine resistance Colchicine/*therapeutic use Depression/complications Familial Mediterranean Fever/*drug therapy/etiology Female female arthritis adolescent General Earth and Planetary Sciences Depressão disease duration proteinuria Febre familiar do Mediterrâneo erythema prospective study |
| Zdroj: | Revista Brasileira de Reumatologia (English Edition). 54:356-359 |
| ISSN: | 2255-5021 |
| Popis: | Introduction: Colchicine is the mainstay for the treatment of FMF, which is an auto-inflammatory disease mainly with relapsing polyserositis. Despite daily doses of 2 mg ormore each day, approximately 5% to 10% of the patients continue to suffer from its attacks. In this study, we aimed to investigate the depression and attack features in patients withFMF who have colchicine resistance (CR).Patients e Methods: CR was defined for FMF patients with 2 or more attacks within the last6 months period while using 2 mg/day colchicine. Eighteen patients (9 Female/9 Male) wereenrolled into the CR group and 41 patients were enrolled into the control group (12 Male/29Female). Demographic, clinical e laboratory findings, treatment adherence, and the BeckDepression Inventory (BDI) scores were evaluated. Results: The age of onset of FMF was significantly lower in the CR group (12.3 yrs vs. 16.9 yrs, P = 0.03). Disease duration was longer in the CR group (P = 0.01). Abdominal and leg pain dueto exercise were significantly more frequent in the CR group versus controls (83% vs. 51%;P = 0.02 e 88% vs. 60%; P = 0.04, respectively). Patients with BDI scores over 17 points weremore frequent in the CR group compared to controls (50% vs. 34.1%; P < 0.001).Discussion: We found that: (1) the age of disease onset was lower and (2) the disease durationwas longer in CR group. Pleuritic attacks, hematuria e proteinuria were more frequent in CRpatients. We propose that depression is an important factor to consider in the susceptibilityto CR. © 2014 Elsevier Editora Ltda. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|