Hydrogen‑rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus‑activated kinase 2/signal transducer and activator of transcription 3 signaling pathway
| Autor: | Yugang Diao, Wanwei Dong, Keyan Chen, Tiezheng Zhang, Yingjie Sun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
biology Kinase Inflammation 030204 cardiovascular system & hematology Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oncology chemistry Apoptosis 030220 oncology & carcinogenesis Myeloperoxidase Lactate dehydrogenase biology.protein medicine STAT protein Tumor necrosis factor alpha medicine.symptom STAT3 |
| Zdroj: | Oncology Letters. |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2018.8639 |
| Popis: | The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to investigate its potential regulation of the Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway. The HRS treatment resulted in the significant upregulation of malonyl dialdehyde (MDA) and myeloperoxidase (MPO), whilesuperoxide dismutase (SOD) levels were significantly downregulated, compared with the Sham group (P |
| Databáze: | OpenAIRE |
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