Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?

Autor: Sally Cristina Moutinho Monteiro, Maria do Desterro Soares Brandão Nascimento, Rui Costa, Ismael Dale Cotrim Guerreiro da Silva, Leonardo Victor Galvão-Moreira, Rita da Graça Carvalhal Frazão Corrêa, Clariano Pires de Oliveira Neto, Luciane Maria Oliveira Brito, Joyce Pinheiro Leal Costa, Flávia Castello Branco Vidal, Haissa Oliveira Brito, José Albuquerque de Figueiredo Neto
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
medicine.medical_specialty
Article Subject
lcsh:Medicine
Coronary Artery Disease
030204 cardiovascular system & hematology
Risk Assessment
lcsh:Technology
General Biochemistry
Genetics and Molecular Biology
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Sex Factors
Risk Factors
Internal medicine
medicine
Odds Ratio
Humans
Public Health Surveillance
Papillomaviridae
lcsh:Science
General Environmental Science
Aged
Climacteric
biology
business.industry
lcsh:T
Papillomavirus Infections
lcsh:R
HPV infection
Age Factors
General Medicine
Odds ratio
Middle Aged
medicine.disease
biology.organism_classification
Confidence interval
3. Good health
Coronary arteries
medicine.anatomical_structure
Socioeconomic Factors
030220 oncology & carcinogenesis
Female
lcsh:Q
business
Risk assessment
Research Article
Zdroj: The Scientific World Journal, Vol 2019 (2019)
The Scientific World Journal
ISSN: 2356-6140
DOI: 10.1155/2019/1872536
Popis: Background. Cardiovascular diseases are leading causes of death worldwide. Recent studies suggest that infection by some viruses, including the human papillomavirus (HPV), may increase the risk of developing atheromatous lesions on coronary arteries. However, there is a lack of data regarding the possible association between HPV infection and coronary artery disease (CAD) in women. Objective. To investigate whether HPV infection is associated with the occurrence of CAD among climacteric women. Methods. The presence of CAD and cervical HPV DNA was investigated in 52 climacteric women. Social and demographic variables and metabolic profiles were also investigated. Results. Among 27 women with CAD, 16 were positive for HPV, whereas 11 were negative. The presence of cervical HPV was strongly associated with CAD, after adjusting for demographic variables, health and sexual behaviors, comorbidities, and known cardiovascular risk factors. HPV-positive women showed a greater likelihood of having CAD (odds ratio [OR] = 3.74; 95% confidence interval [CI]: 1.16 to 11.96) as compared with HPV-negative women, particularly those infected with high-risk HPV types (OR = 4.90; 95% CI: 1.26 to 19.08). Conclusion. These results support the hypothesis that HPV infection might be associated with CAD among climacteric women, though further studies are needed to investigate the mechanisms involved.
Databáze: OpenAIRE
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