Analgesic effects of repetitive transcranial magnetic stimulation on modified 2010 criteria-diagnosed fibromyalgia: Pilot study
| Autor: | Mu Hong Chen, Shung Tai Ho, Wen Han Chang, Chih Ming Cheng, Jen Chuen Hsieh, Nien Tzu Kao, Tung Ping Su, Cheng Ta Li, Shuu Jiun Wang, Ya Mei Bai |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Fibromyalgia medicine.medical_treatment Analgesic Prefrontal Cortex Pilot Projects Comorbidity behavioral disciplines and activities Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Double-Blind Method Rating scale Internal medicine mental disorders Outcome Assessment Health Care medicine Humans Pain Management Generalized estimating equation Depression (differential diagnoses) Depressive Disorder Major business.industry General Neuroscience General Medicine Middle Aged medicine.disease Transcranial Magnetic Stimulation Rheumatology 030227 psychiatry Transcranial magnetic stimulation Psychiatry and Mental health Neurology Major depressive disorder Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry and clinical neurosciences. 73(4) |
| ISSN: | 1440-1819 |
| Popis: | AIM Fibromyalgia is often comorbid with depression, and less than half those patients achieve satisfactory improvement after adequate pharmacological intervention. The investigation of repetitive transcranial magnetic stimulation (rTMS) at left dorsolateral prefrontal cortex for modified-2010 American College of Rheumatology (ACR) fibromyalgia and major depressive disorder (MDD) is still in its infancy. METHODS In this double-blind, randomized, sham-control study, subjects diagnosed with ACR-2010 fibromyalgia and DSM-IV-TR MDD were recruited and received either active or sham interventions for 2 weeks. Hamilton Depression Rating Scale (HDRS) and the 10-cm visual analogue pain scale were evaluated at baseline, week 1, and week 2. Multivariable generalized estimating equations analysis was performed for the association between depression and pain scores at each checkpoint. RESULTS Twenty subjects were recruited. There was a significant difference over the 2 weeks between the rTMS and sham stimulation groups (P = 0.029), but subgroup analyses were further performed due to significant interaction of group and HDRS on pain outcomes (P = 0.020). The active group had significant improvement in pain at week 2 compared with week 1 (P = 0.021), but the control group did not have any improvement in pain (P = 0.585). Of the mild-moderate depression patients, the pain score in the active group was significantly lower than in the sham group at week 1 (P = 0.001) and at week 2 (P |
| Databáze: | OpenAIRE |
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