Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
| Autor: | Yan-Dong Miao, Jiang-Tao Wang, Xiao-Long Tang, Deng-Hai Mi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gastroenterology
General Medicine Pancreatic cancer Dendritic Cells CXCL12 Th1 Cells Microarray Analysis Splicing isoforms Chemokine CXCL12 Killer Cells Natural Pancreatic Neoplasms Bioinformatics analysis Tumor microenvironment embryonic structures Humans Protein Isoforms Letter to the Editor Pathway |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, P < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway. |
| Databáze: | OpenAIRE |
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