Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis
| Autor: | Cheng Weijia, Xiao Li, Chaochu Cui, Dongling Liu, Xianwei Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Epithelial-Mesenchymal Transition
Heart Diseases Cardiac fibrosis 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Tgf β signaling microRNA medicine Animals Humans Pharmacology (medical) 030304 developmental biology Pharmacology 0303 health sciences business.industry Myocardium Mesenchymal stem cell Endothelial Cells medicine.disease Fibrosis Endothelial stem cell Cancer research Cardiology and Cardiovascular Medicine business Signal Transduction |
| Zdroj: | Journal of Cardiovascular Pharmacology and Therapeutics. 26:3-11 |
| ISSN: | 1940-4034 1074-2484 |
| DOI: | 10.1177/1074248420952233 |
| Popis: | Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions. |
| Databáze: | OpenAIRE |
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